Marcelli-Barge A, Poirier J C, Benajam A, Dausset J
Rev Fr Transfus Immunohematol. 1976 Mar;19(1):253-64. doi: 10.1016/s0338-4535(76)80104-3.
The antigen Atri can be detected on the lymphocytes of 5.19% of ABH Secretor A individuals. The Atri substance is present in the plasma of the same individuals and can be fixed on group O erythrocytes. It is also found in the saliva of 30/32 A individuals not secreting substance A. Its existence in the saliva of A Secretor individuals, however, cannot be proved due to the presence of both the A and Atri antigens. The Atri substance is neutralized by the soluble substance A extracted from the gastric mucous of a pig. Yet the A and Atri antigens can be shown to be distinct on lymphocytes by redistribution of the corresponding sites and blocking of the A sites by an immune anti-A. On a genetic level, the Atri specificity might belong to a lymphocyte system comprising three alleles: Atri, RB and W100. These three specificities have the common characteristic of being expressed on a certain percentage of the lymphocytes of group A individuals. This system, provisionally named Atri, is functionally associated with the ABO system and secretor system. Nevertheless, the fact that in several families the Atri antigen is not expressed by the parents shows that its expression on lymphocytes requires the intervention of at least one gene in addition to the A and Se genes.
抗原Atri可在5.19%的ABH分泌型A个体的淋巴细胞上检测到。Atri物质存在于相同个体的血浆中，并可固定在O型红细胞上。在32名不分泌A物质的A个体中，有30名的唾液中也发现了该物质。然而，由于A和Atri抗原同时存在，无法证明其在A分泌型个体唾液中的存在。Atri物质可被从猪胃黏膜中提取的可溶性A物质中和。然而，通过相应位点的重新分布以及免疫抗A对A位点的封闭，可证明A和Atri抗原在淋巴细胞上是不同的。在基因层面上，Atri特异性可能属于一个包含三个等位基因的淋巴细胞系统：Atri、RB和W100。这三种特异性的共同特征是在一定比例的A血型个体的淋巴细胞上表达。这个系统暂名为Atri，在功能上与ABO系统和分泌型系统相关。然而，在几个家族中，父母并不表达Atri抗原，这一事实表明，其在淋巴细胞上的表达除了A和Se基因外，还至少需要一个基因的参与。
