Gozariu L, Florescu O, Vasile V, Suciu E, Dumitru E, Rosan L, Dascălu R
Endocrinologie. 1976 Jul-Sep;14(3):213-8.
Studies on patients with severe hyperthyroidism revealed an increased skeletal avidity for calcium, expressed in terms of net retention, after a three-hour i.v. load of 10mg Ca/kg body weight. For the same hyperthyroid subjects the calcitonin inactivating potency of the sera was tested in vitro. The results were expressed as restant hypocalcemic potency of the calcitonin after incubation with the serum fractions. In hyperthyroid subjects two fractions in dilutions of 1:10 reduced the hypocalcemic activity of calcitonin by 75%. In normals this activity appeared only in one fraction. All these results suggest a prompt calcitonin release during calcium infusion which is however less efficient, probably because of the increased amount of calcitonin inactivating factor present in sera. The serum inactivating factor generally contributes to the short-time activity of calcitonin both in normals and in some clinical states with bone calcium imbalance.
对重度甲状腺功能亢进患者的研究表明，在静脉注射10mg钙/千克体重三小时后，以净潴留量表示，骨骼对钙的亲和力增加。对于同样的甲状腺功能亢进受试者，在体外测试了血清中降钙素的失活能力。结果以与血清组分孵育后降钙素的剩余降钙活性表示。在甲状腺功能亢进受试者中，两种稀释度为1:10的组分使降钙素的降钙活性降低了75%。在正常人中，这种活性仅出现在一种组分中。所有这些结果表明，在钙输注过程中降钙素迅速释放，然而效率较低，可能是因为血清中存在的降钙素失活因子数量增加。血清失活因子通常对正常人和一些骨钙失衡的临床状态下降钙素的短期活性有影响。
