Smith S D, Cason Z, Cabaniss D E, Benghuzzi H A, Lemos L B
Department of Cytotechnology and Health Sciences, University of Mississippi Medical Center, USA.
Biomed Sci Instrum. 1997;33:286-91.
Fine needle aspiration biopsy (FNAB) has become a widely used and accepted procedure to detect benign and malignant lesions of the breast. In the past, highly invasive procedures were used in the investigation of suspect breast tumors. Surgical excision was the method of choice during this period often requiring hospitalization of the patient. However, the recent introduction of FNAB has allowed a less traumatic approach for such investigations. Due to pressures from Health Management Organizations (HMO's), FNAB is presently the method of choice allowing for decreased patient trauma, expense, and ability of the procedure to be performed on an outpatient basis. Although highly accepted by most clinicians, others suggest that FNAB should perform diagnostically at a level equivalent or higher than that obtainable by frozen tissue sectioning procedures. This study was designed to evaluate the diagnostic ability of FNAB. Four-hundred twenty-seven patients underwent FNAB during 1993-94 at the University of Mississippi Medical Center. Of those patients, two hundred thirty-seven also underwent corresponding surgical biopsies. Sensitivity (88%), specificity (96%), a false positive rate (4%), and a false negative rate (12%) were calculated from the data and reported. In conclusion, the diagnostic accuracy of FNAB of the breast determined in this study shows the significance of the procedure.
细针穿刺活检（FNAB）已成为一种广泛应用且被认可的用于检测乳腺良恶性病变的方法。过去，在对可疑乳腺肿瘤进行检查时采用的是侵入性很强的方法。手术切除是这一时期的首选方法，通常需要患者住院。然而，最近FNAB的引入为这类检查提供了一种创伤较小的方法。由于健康管理组织（HMO）的压力，目前FNAB是首选方法，它能减少患者的创伤、费用，并可在门诊进行。尽管大多数临床医生高度认可FNAB，但也有人认为FNAB的诊断水平应等同于或高于冷冻组织切片检查所能达到的水平。本研究旨在评估FNAB的诊断能力。1993年至1994年期间，密西西比大学医学中心有427名患者接受了FNAB。在这些患者中，有237人还接受了相应的手术活检。根据数据计算并报告了敏感性（88%）、特异性（96%）、假阳性率（4%）和假阴性率（12%）。总之，本研究确定的乳腺FNAB诊断准确性显示了该方法的重要性。
