Schulz S, Bauernschmitt R, Albers J, Riesenberg A, Schwarzhaupt A, Vahl C F, Kiencke U
Dept. of Cardiac Surgery SFB 414, University of Heidelberg, Germany.
Biomed Sci Instrum. 1997;33:406-11.
The purpose of the following study was to establish a computer-generated model of the hemodynamic effects of pulsatile extracorporal perfusion describing flow and pressure parameters in the body for any given input flow patterns.
The human arterial tree was delineated according to a 128-branch model encompassing bifurcations and linear physical properties of the arterial walls. The distribution of flow and pressure waves was calculated based on a refined 3-element windkessel model. Autoregulatory mechanisms of brain and kidneys were implemented.
By providing a simulated, "pump-generated" flow curve as the input signal to the system, the model was able to create and display flow and pressure curves at a high time resolution in each part of the systemic circulation including reflection phenomena throughout any observation period chosen. The hemodynamic effects of different pump-flow patterns, age, variations in hematocrit, hypothermia and occlusion of arterial branches, like the renal artery, could be simulated.
In an attempt to get closer to a mathematically based regulation of heart-lung machines, this model of computer generated extracorporeal circulation provides an initial step. Ongoing research is required for implementation of metabolic conditions and continuous approximation of the model of the real physiologic or pathologic situation.
以下研究的目的是建立一个计算机生成的搏动性体外灌注血流动力学效应模型，用于描述在任何给定输入血流模式下体内的血流和压力参数。
根据包含动脉壁分支和线性物理特性的128分支模型描绘人体动脉树。基于改进的三元件风箱模型计算血流和压力波的分布。实施大脑和肾脏的自动调节机制。
通过将模拟的“泵产生的”血流曲线作为系统的输入信号，该模型能够在全身循环的每个部分以高时间分辨率创建和显示血流和压力曲线，包括在任何选定观察期内的反射现象。可以模拟不同泵血流模式、年龄、血细胞比容变化、低温以及动脉分支（如肾动脉）闭塞的血流动力学效应。
为了更接近基于数学的心肺机调节，这个计算机生成的体外循环模型提供了第一步。实施代谢条件并不断逼近真实生理或病理情况的模型需要持续研究。
