Vitiligo and malignant melanoma: a significant association?

Three patients with malignant melanoma and coexisting vitiligo are described. All three appear to exhibit at least partial spontaneous control of the melanoma. The hypothesis is made that there may be a significant association between vitiligo and regressing melanoma. The basis for this is the fact that there may be an association between vitiligo and the production of an antimelanoma antibody, promoting rejection of the melanoma.