Strumìa R, Lombardi A R, Bedani P L, Perini L
Clinica Dermatologica, Università di Ferrara, Italy.
J Eur Acad Dermatol Venereol. 1998 Jul;11(1):69-71.
Several types of soft tissue calcification can be detected from radiographic evaluation of patients with end-stage renal failure. The factors that predispose to such calcification include an increase in CaxP product in serum, the degree of secondary hyperparathyroidism, the level of blood magnesium, the degree of alkalosis, and the presence of local tissue injury. Three major varieties include calcification of medium-sized arteries, periarticular or tumoral calcification and visceral calcification. Calciphylaxis is a phenomenon consisting of acute ischemic necrosis in presence of calcification of dermohypodermic arterioles. It occurs mostly in chronic renal failure patients with secondary or tertiary hyperparathyroidism with a persistently elevated calcium-phosphorus product. There are few options in treating calciphylaxis and the outcome is generally poor. The authors report the case of a haemodialised patient with benign nodular calcification and calciphylaxis. The coexistence of both entities in the same patient has never been described.
通过对终末期肾衰竭患者进行影像学评估，可以检测到几种类型的软组织钙化。易发生这种钙化的因素包括血清中钙磷乘积增加、继发性甲状旁腺功能亢进的程度、血镁水平、碱中毒程度以及局部组织损伤的存在。三种主要类型包括中等大小动脉钙化、关节周围或肿瘤性钙化以及内脏钙化。钙化防御是一种在真皮皮下小动脉钙化的情况下发生急性缺血性坏死的现象。它主要发生在患有继发性或三发性甲状旁腺功能亢进且钙磷乘积持续升高的慢性肾衰竭患者中。治疗钙化防御的选择很少，而且结果通常很差。作者报告了一例接受血液透析的患者，该患者同时存在良性结节性钙化和钙化防御。同一患者中这两种情况并存的情况此前从未有过描述。
