放射性6β-碘甲基-19-去甲胆甾-5(10)-烯-3β-醇的合成与纯化
Synthesis and purification of radioactive 6beta-iodomethyl-19-norcholest-5(10)-en-3beta-ol.
作者信息
Scott K N, Couch M W, Mareci T H, Williams C M
出版信息
Steroids. 1976 Aug;28(2):295-303. doi: 10.1016/0039-128x(76)90117-3.
PMID:973240
Abstract
A method for the synthesis and purification of 6beta-iodomethyl-19-norcholest-5(10)-ene-3beta-ol-131I of greater than 98 mole% chemical purity and greater than 99% radiochemical purity is presented. Carbon-13 and proton NMR were used to establish the identity and purity. Discrepancies in the characterization of this compound, previously published by two other research groups, are discussed.
摘要
本文介绍了一种合成和纯化化学纯度大于98摩尔%、放射化学纯度大于99%的6β-碘甲基-19-降胆甾-5(10)-烯-3β-醇-131I的方法。采用碳-13和质子核磁共振波谱确定其结构和纯度。文中还讨论了另外两个研究小组此前发表的关于该化合物表征的差异。
Zotero 插件