Greenough W B, Hirschhorn N, Gordon R S, Lindenbaum J, Ally K M
Trop Geogr Med. 1976 Jun;28(2):86-90.
Five patients with severe acidosis and pulmonary oedema complicating cholera were seen at the Cholera Research Laboratory, Dacca, in a two-year period. All had had inadequate treatment. Their disease resulted in acidosis prior to admission; only the two who subsequently survived received volumes of sodium bicarbonate solutions sufficiently large to repair completely their acidosis. Saline alone worsened pulmonary congestion, while alkali appeared to relieve it despite the accompanying volume expansion. These observations are consistent with the known redistribution of blood to the central circulation in acidosis. Timely and proper treatment of cholera will avert this syndrome, when use of isotonic sodium bicarbonate sufficient to correct acidosis may be very helpful.
在达卡霍乱研究实验室，两年内共收治了5例并发严重酸中毒和肺水肿的霍乱患者。所有患者均治疗不充分。他们在入院前就已因疾病导致酸中毒；只有随后存活的2例患者接受了足量的碳酸氢钠溶液，足以完全纠正其酸中毒。单独使用生理盐水会加重肺充血，而碱性溶液尽管会伴随血容量增加，但似乎能缓解肺充血。这些观察结果与酸中毒时血液重新分布至中心循环的已知情况相符。及时且恰当地治疗霍乱可避免该综合征，此时使用足以纠正酸中毒的等渗碳酸氢钠可能会非常有帮助。
