Delbarre M, Joly P, Balguerie X, Thomine E, Lauret P
Clinique Dermatologique, Hôpital Charles Nicolle, Rouen.
Ann Dermatol Venereol. 1997;124(12):841-4.
Topical non steroidal antiinflammatory drugs (NSAID) are recently used in France. Seven cases of contact vasculitis due to topical NSAID are reported.
The clinical and histological features and follow-up data of seven patients with contact vasculitis due to topical NSAID were retrospectively reviewed.
The mean age of the seven patients (four women, three men) was 39 years. The topical NSAID used were: ketoprofene in four cases, mephenesine in one case and phenylbutazone in two cases. Cutaneous lesions occurred after a mean time of four days. Histological examination of a skin biopsy specimen showed a leucocytoclastic vasculitis in two cases, a lymphocytic vasculitis in two cases and a mixed vasculitis in three cases. Previous sensibilization to the drug was noted in five cases. Cutaneous patch tests with the drugs were positive in all cases.
The risk of systemic reaction after oral ingestion of the culprit drug may be considered in these patients.
