Billard V, Cazalaà J B, Servin F, Viviand X
Service d'anesthésie, institut Gustave-Roussy, Villejuif, France.
Ann Fr Anesth Reanim. 1997;16(3):250-73. doi: 10.1016/s0750-7658(97)86410-6.
Target-controlled infusion (TCI) is a new delivery system for i.v. anaesthetic agents with which the anaesthetist targets a plasma drug concentration to achieve a predetermined effect. With this system, the tedious task of calculating the amount of administered drug required to achieve the target concentration is left in charge of a microprocessor which commands the infusion device. TCI has long been used only by a few research teams, but this year a much wider field opens to this delivery system through marketing of Diprifusor, a TCI system specifically designed for administration of propofol in everyday practice. This article describes the rationale for administering i.v. agents through TCI delivery systems, the pharmacokinetic basis of TCI, the regulations and a broad overview of clinical applications, both recent and yet to come.
靶控输注（TCI）是一种用于静脉麻醉药物的新型给药系统，麻醉医生可通过该系统将血浆药物浓度作为目标，以达到预定的麻醉效果。借助此系统，计算达到目标浓度所需给药量这一繁琐任务由微处理器负责，微处理器控制输注设备。长期以来，只有少数研究团队使用TCI，但今年随着Diprifusor的上市，这一给药系统迎来了更广阔的应用领域，Diprifusor是一款专为日常临床使用丙泊酚而设计的TCI系统。本文介绍了通过TCI给药系统静脉给药的基本原理、TCI的药代动力学基础、相关规定以及对近期和未来临床应用的全面概述。
