Melato M, Gorji N
Department of Pathology, University of Trieste, Italy.
Am J Gastroenterol. 1998 Sep;93(9):1592-3. doi: 10.1111/j.1572-0241.1998.00492.x.
Primary cryptococcal infection is thought to arise in the lungs, whereas secondary lesions may be found anywhere in the body. Because intestinal involvement is rare, especially in nonimmunocompromised patients, little is known about this localization. Nevertheless, the intestinal tract has long been suggested a possible portal of entry of Cryptococcus neoformans, although the hypothesis has never been sufficiently documented. We report an isolated cryptococcosis of the sigmoid colon mimicking an adenomatous polyp. The lesion has an endoscopic interest, being the first of its kind reported in the literature, and a more important pathogenic interest, as it highlights a further pathway of cryptococcal infection, one of major importance in immunocompromised patients.
原发性隐球菌感染被认为起源于肺部，而继发性病变可能出现在身体的任何部位。由于肠道受累情况罕见，尤其是在非免疫功能低下的患者中，人们对这种定位知之甚少。然而，长期以来一直有人提出肠道可能是新型隐球菌的一个潜在入口，尽管这一假说从未得到充分证实。我们报告了一例孤立的乙状结肠隐球菌病，其表现类似腺瘤性息肉。该病变在内镜检查方面具有研究价值，是文献中报道的首例此类病例，在致病方面也具有更重要的意义，因为它凸显了隐球菌感染的另一条途径，这在免疫功能低下的患者中至关重要。
