慢性肾衰竭中的氧化应激
Oxidative stress in chronic renal failure.
作者信息
Hasselwander O, Young I S
机构信息
Department of Clinical Biochemistry, The Queen's University of Belfast, and the Royal Group of Hospitals, Northern Ireland.
出版信息
Free Radic Res. 1998 Jul;29(1):1-11. doi: 10.1080/10715769800300011.
PMID:9733016
Abstract
Cardiovascular disease is the major cause of morbidity and mortality in chronic renal failure. The aim of this review is to summarise current evidence suggesting that there is increased free radical production, antioxidant depletion and changes in lipoprotein composition in renal failure which will lead to oxidation of LDL and hence to accelerated development of atherosclerosis.
摘要
心血管疾病是慢性肾衰竭发病和死亡的主要原因。本综述的目的是总结当前的证据，这些证据表明，肾衰竭时自由基生成增加、抗氧化剂耗竭以及脂蛋白组成发生变化，这将导致低密度脂蛋白氧化，从而加速动脉粥样硬化的发展。
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