Cao Yuyu, Zhou Yishan, Zhong Yanghong, Liao Xianyong, Chen Xushan, Pi Ying
Seventh Clinical Medical College, Guangzhou University of Chinese Medicine, Shenzhen, China.
Front Nutr. 2024 Apr 23;11:1374719. doi: 10.3389/fnut.2024.1374719. eCollection 2024.
Oxidative stress status is associated with CKD; however, few studies have investigated this association. The oxidative balance score (OBS) reflects systemic stress status and consists of 16 anti-and pro-oxidant dietary factors and four anti-and pro-oxidant lifestyle factors. Higher OBS implies exposure to more antioxidants. The purpose of this study was to explore the association between OBS and CKD.
We enrolled 8,134 study participants from the 2011-2018 National Health and Nutrition Examination Survey and obtained OBS by adding the 20 dietary and lifestyle factors. Based on OBS, the participants were divided into three groups. We performed logistic regression, subgroup analyzes, and restricted cubic spline regression to explore the association between OBS and CKD. In addition, we tested the adjusted model.
OBS was negatively associated with CKD (OR: 0.54; 0.66, 0.82). After adjusting for all confounders, when dietary OBS was >20, the prevalence of CKD was reduced by 42% for each unit increase in OBS ( < 0.05). The negative associations of total OBS, dietary OBS, and lifestyle OBS with CKD were more significant in the female group. When the total OBS was ~20, the trend of decreasing prevalence in the female group was more significant.
OBS is negatively associated with chronic kidney disease.
氧化应激状态与慢性肾脏病（CKD）相关；然而，很少有研究调查这种关联。氧化平衡评分（OBS）反映全身应激状态，由16种抗氧化和促氧化饮食因素以及4种抗氧化和促氧化生活方式因素组成。较高的OBS意味着接触更多的抗氧化剂。本研究的目的是探讨OBS与CKD之间的关联。
我们从2011 - 2018年全国健康与营养检查调查中纳入了8134名研究参与者，并通过将20种饮食和生活方式因素相加得到OBS。根据OBS，将参与者分为三组。我们进行了逻辑回归、亚组分析和受限立方样条回归，以探讨OBS与CKD之间的关联。此外，我们还测试了调整模型。
OBS与CKD呈负相关（比值比：0.54；95%置信区间：0.66，0.82）。在对所有混杂因素进行调整后，当饮食OBS>20时，OBS每增加一个单位，CKD的患病率降低42%（P<0.05）。总OBS、饮食OBS和生活方式OBS与CKD的负相关在女性组中更显著。当总OBS约为20时，女性组患病率下降的趋势更显著。
OBS与慢性肾脏病呈负相关。
