一个在爱泼斯坦-巴尔病毒生命周期后期进程中所需的功能独特的TATA框。
A functionally distinct TATA box required for late progression through the Epstein-Barr virus life cycle.
作者信息
Serio T R, Cahill N, Prout M E, Miller G
机构信息
Department of Molecular Biophysics and Biochemistry, New Haven, Connecticut 06520, USA.
出版信息
J Virol. 1998 Oct;72(10):8338-43. doi: 10.1128/JVI.72.10.8338-8343.1998.
Abstract
During EBV infection, lytic DNA replication activates late gene expression in trans via an uncharacterized pathway. In this study, we mapped the target of this regulatory cascade to a variant TATA box (TATTAAA) and the 3' flanking region within the core promoter of the BcLF1 gene. The inherent late activity of this core promoter is, surprisingly, disrupted by a heterologous enhancer, suggesting that late gene expression is regulated through core promoter sequences located in a transcriptionally inert environment.
摘要
在EB病毒感染期间，裂解性DNA复制通过一条未明确的途径反式激活晚期基因表达。在本研究中，我们将这一调控级联反应的靶点定位到BcLF1基因核心启动子内的一个变异TATA盒（TATTAAA）和3'侧翼区域。令人惊讶的是，该核心启动子固有的晚期活性被一个异源增强子破坏，这表明晚期基因表达是通过位于转录惰性环境中的核心启动子序列来调控的。
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本文引用的文献
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J Virol. 1998 Oct;72(10):7978-84. doi: 10.1128/JVI.72.10.7978-7984.1998.
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Late gene expression from the Epstein-Barr virus BcLF1 and BFRF3 promoters does not require DNA replication in cis.爱泼斯坦-巴尔病毒BcLF1和BFRF3启动子的晚期基因表达不需要顺式DNA复制。
J Virol. 1997 Nov;71(11):8726-34. doi: 10.1128/JVI.71.11.8726-8734.1997.
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