Temple C S, Boyd C A
Department of Human Anatomy, University of Oxford, South Parks Road, Oxford OX1 3QX, UK.
Biochim Biophys Acta. 1998 Aug 14;1373(1):277-81. doi: 10.1016/s0005-2736(98)00093-5.
We demonstrate that the angiotensin-converting enzyme inhibitors enalapril and captopril inhibit the transport of D-Phe-L-Gln into PepT1-expressing Xenopus oocytes and into rat renal cortical brush border membrane vesicles (BBMV). The kinetics of inhibition are competitive. Enalapril and captopril are not substrates for PepT2 (Boll et al., Proc. Natl. Acad. Sci. 93 (1996) 284-289). Therefore we conclude that in rat renal cortical BBMV this neutral dipeptide is transported via PepT1.
我们证明，血管紧张素转换酶抑制剂依那普利和卡托普利可抑制D-苯丙氨酸-L-谷氨酰胺转运至表达PepT1的非洲爪蟾卵母细胞以及大鼠肾皮质刷状缘膜囊泡（BBMV）中。抑制动力学呈竞争性。依那普利和卡托普利不是PepT2的底物（Boll等人，《美国国家科学院院刊》93 (1996) 284 - 289）。因此我们得出结论，在大鼠肾皮质BBMV中，这种中性二肽是通过PepT1转运的。
