Rejtö L, Schlammadinger A, László P, Kiss A, Telek B, Boda Z
Debreceni Orvostudományi Egyetem, II. Belgyógyászati Klinika.
Orv Hetil. 1998 Aug 16;139(33):1961-4.
In the differential diagnosis of primary and secondary thrombocytosis, platelet function test can be used. We have examined the possible role of O'Brien's filter test in the differentiation of primary and secondary thrombocytosis in 53 patients with myeloproliferative diseases with primary thrombocytosis and in 21 patients with other disorders complicated by secondary thrombocytosis. By using heparin as an anticoagulant, the sensitivity of O'Brien's filter test proved to be 75%, and it's specificity was 85.7%. In blood samples anticoagulated with citrate, the sensitivity was 100% and specificity 83.3%. Based on these studies we suggest the use of O'Brien's filterometer as a screening test in the differential diagnosis in patients with elevated (> 400 x 10(9)/L) platelet count. In case of normal results, the causes of reactive thrombocytosis should be cleared first, while with pathologic results, haematological examination of the patients should be performed.
在原发性和继发性血小板增多症的鉴别诊断中，可采用血小板功能试验。我们已检测了奥布赖恩滤过试验在53例原发性血小板增多症的骨髓增殖性疾病患者以及21例并发继发性血小板增多症的其他疾病患者中对原发性和继发性血小板增多症鉴别的可能作用。以肝素作为抗凝剂时，奥布赖恩滤过试验的敏感性为75%，特异性为85.7%。在用柠檬酸盐抗凝的血样中，敏感性为100%，特异性为83.3%。基于这些研究，我们建议将奥布赖恩滤过仪用作血小板计数升高（>400×10⁹/L）患者鉴别诊断的筛查试验。如果结果正常，应首先明确反应性血小板增多症的病因，而结果为病理性时，则应对患者进行血液学检查。
