Kirkpatrick B, Ram R, Amador X F, Buchanan R W, McGlashan T, Tohen M, Bromet E
Department of Psychiatry, Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, USA.
Am J Psychiatry. 1998 Sep;155(9):1221-6. doi: 10.1176/ajp.155.9.1221.
Patients with the deficit syndrome differ from other patients with schizophrenia relative to physiological correlates, course of illness, and response to treatment. Because of the abnormal seasonality of birth among persons with schizophrenia, the authors examined the relation between this risk factor and the deficit syndrome.
Findings in two clinical groups suggested an increase in summer births among deficit syndrome patients. The association between summer birth and the deficit syndrome was then examined in a catchment area study of first-admission patients with psychosis.
In the catchment area sample, summer birth was also significantly associated with the deficit syndrome; negative symptoms broadly defined were not.
These findings add to the increasing evidence that 1) patients with the deficit syndrome have a disease with an etiopathophysiology separate from that of other patients with what is now called schizophrenia and 2) the correlates of broadly defined negative symptoms are different from those for the deficit syndrome. The previously reported association between winter birth and schizophrenia appears to apply to nondeficit schizophrenia only.
缺损综合征患者在生理相关性、病程及对治疗的反应方面与其他精神分裂症患者有所不同。鉴于精神分裂症患者出生季节的异常情况，作者研究了这一风险因素与缺损综合征之间的关系。
两个临床组的研究结果表明，缺损综合征患者夏季出生的比例有所增加。随后在一项针对首次入院的精神病患者的集水区研究中，对夏季出生与缺损综合征之间的关联进行了研究。
在集水区样本中，夏季出生也与缺损综合征显著相关；而广义定义的阴性症状则不然。
这些发现进一步证明：1）缺损综合征患者所患疾病的病因病理生理学与现在所称的其他精神分裂症患者不同；2）广义定义的阴性症状的相关因素与缺损综合征的相关因素不同。先前报道的冬季出生与精神分裂症之间的关联似乎仅适用于非缺损型精神分裂症。
