Pansegrau K J, Fridrich K L, Lew D, Keller J C
University of Iowa, Iowa City, USA.
J Oral Maxillofac Surg. 1998 Sep;56(9):1067-73; discussion 1073-4. doi: 10.1016/s0278-2391(98)90258-0.
This study was undertaken to compare the rate and degree of osseointegration of dental implants when placed into either autogenous corticocancellous chip or freeze-dried corticocancellous chip bone grafts.
The canine ilium was used as the model site. Thirty experimental and 15 control implants were placed in 15 dogs: autogenous versus freeze-dried corticocancellous chip bone grafts around the exposed implant surfaces. In addition to the placement of control implants, the apical portion of the grafted implants acted as their own control. The implants were harvested at 1, 2, and 3 months. The evaluation of the integration process was performed by means of light microscopy, microradiography, and histomorphometry.
Using this model, the results indicate that at 1 month there was no statistical difference in the degree of osseointegration in the two bone grafts. At 2 months, there was a statistically greater degree of osseointegration noted in the autogenous corticocancellous chip sites than in the freeze-dried bone grafts. At 3 months, the degree of osseointegration in the two groups was 70% and 33%, respectively. At 3 months, there was virtually 100% integration with trabecular bone at the control implant sites.
The results indicate that at 2 months postoperatively implants placed in an autogenous bone chip graft osseointegrate to a significantly greater degree than implants placed in a freeze-dried bone chip graft, and this difference remains at 3 months.
本研究旨在比较牙种植体植入自体皮质松质骨碎骨片或冻干皮质松质骨碎骨片骨移植区时的骨结合率和骨结合程度。
以犬髂骨作为模型部位。在15只犬体内植入30颗实验性种植体和15颗对照种植体：在暴露的种植体表面周围分别植入自体皮质松质骨碎骨片和冻干皮质松质骨碎骨片。除了植入对照种植体，移植种植体的根尖部分作为自身对照。分别在1、2和3个月时取出种植体。通过光学显微镜、显微放射摄影和组织形态计量学对骨结合过程进行评估。
使用该模型，结果表明，在1个月时，两种骨移植区的骨结合程度无统计学差异。在2个月时，自体皮质松质骨碎骨片部位的骨结合程度在统计学上显著高于冻干骨移植区。在3个月时，两组的骨结合程度分别为70%和33%。在3个月时，对照种植体部位与小梁骨的结合率几乎达到100%。
结果表明，术后2个月时，植入自体骨碎骨片移植区的种植体骨结合程度显著高于植入冻干骨碎骨片移植区的种植体，且这种差异在3个月时仍然存在。
