Benke T, Bösch S, Andree B
Clinic of Neurology, University Innsbruck, Austria.
Brain Cogn. 1998 Oct;38(1):36-52. doi: 10.1006/brcg.1998.1013.
This study investigated three aspects of processing materials with emotional content in patients with idiopathic Parkinson's disease (PD): the ability to produce affective prosody, to discriminate affectively loaded speech, and to detect the surprise element in humorous sketches. Study aims were the characterization of an emotional processing deficit, and to test whether impaired emotional processing is mental state dependent. Forty-eight nondemented PD patients were divided according to neuropsychological criteria into a sample with intact mental functions and a sample with mild to moderate cognitive deterioration, particularly memory impairment. PD patients with intact cognitive functions were solely impaired at producing affectively loaded sentences, but otherwise displayed normal emotional processing abilities as compared to a clinical control group. PD patients with mental impairment were significantly disabled on all three tasks. The observed emo tional processing deficit was not related to variables like age, disease duration, de gree of functional impairment, motor disability or depression. Active and receptive emotional prosody were significantly correlated. Further strong positive correlations were found between the ability to disclose pictorial humour and tasks of visuoconceptual knowledge, as well as between the ability to produce affectively loaded speech and years of schooling. These results were interpreted as indicating that not only the production of emotional prosody, but also its recognition and the discovery of pictorial humour are reduced in a subgroup of PD patients with mental impairment. Impaired emotional processing skills are mental state dependent findings in PD which seem to be independent from demographic or disease variables and may indicate beginning dementia.
本研究调查了特发性帕金森病（PD）患者处理带有情感内容材料的三个方面：产生情感韵律的能力、辨别带有情感色彩言语的能力以及在幽默小品中察觉意外元素的能力。研究目的是对情感处理缺陷进行特征描述，并测试情感处理受损是否依赖于心理状态。48名无痴呆的PD患者根据神经心理学标准被分为心理功能完好的样本和有轻度至中度认知衰退（尤其是记忆损害）的样本。认知功能完好的PD患者仅在生成带有情感色彩的句子方面受损，但与临床对照组相比，在其他方面表现出正常的情感处理能力。有心理损害的PD患者在所有三项任务上均有明显障碍。观察到的情感处理缺陷与年龄、病程、功能损害程度、运动障碍或抑郁等变量无关。主动和接受性情感韵律显著相关。此外，在揭示图画幽默的能力与视觉概念知识任务之间，以及在生成带有情感色彩言语的能力与受教育年限之间，发现了进一步的强正相关。这些结果被解释为表明，在有心理损害的PD患者亚组中，不仅情感韵律的产生，而且其识别以及图画幽默的发现都有所减少。情感处理技能受损是PD中依赖于心理状态的发现，似乎独立于人口统计学或疾病变量，可能预示着早期痴呆。
