Verleden Stijn, Vingerhoets Guy, Santens Patrick
Laboratory for Neuropsychology, Gent University, Gent, Belgium.
Eur Neurol. 2007;58(1):34-40. doi: 10.1159/000102164. Epub 2007 May 4.
The aim of this study was to examine the heterogeneity of cognitive dysfunction in Parkinson's disease (PD) and to evaluate the contribution of cognitive criteria to the diagnosis of dementia in PD.
In a sample of 100 consecutive PD patients with motor fluctuations, an extensive neuropsychological test battery was administered. Each PD patient's cognitive profile was then compared with current cognitive criteria for dementia in PD.
Principal component analysis of the major test variables resulted in three components: one concerned with memory/attention, one with visuospatial, and one with executive/motor functions. Eighteen percent of our cohort showed no significant impairment on either domain. Fifty-one percent showed impairment in one cognitive domain, most frequently in the executive/motor component (88%). Twenty-four percent performed below normal on two cognitive components, most often executive/motor and memory/attention deficits (96%), and only 7% of our cohort had significant impairment on each derived cognitive component. Depending on the used criteria, 10-30% percent of our cohort could be categorized as PD patients with dementia.
Future guidelines for a uniform diagnosis of dementia in PD are needed for clinical use and therapeutic management.
本研究旨在探讨帕金森病（PD）认知功能障碍的异质性，并评估认知标准对PD痴呆诊断的贡献。
在100例连续的有运动波动的PD患者样本中，进行了广泛的神经心理学测试。然后将每位PD患者的认知概况与当前PD痴呆的认知标准进行比较。
主要测试变量的主成分分析产生了三个成分：一个与记忆/注意力有关，一个与视觉空间有关，一个与执行/运动功能有关。我们队列中的18%在任何一个领域都没有明显受损。51%在一个认知领域有损伤，最常见于执行/运动成分（88%）。24%在两个认知成分上表现低于正常水平，最常见的是执行/运动和记忆/注意力缺陷（96%），我们队列中只有7%在每个衍生的认知成分上有明显损伤。根据所使用的标准，我们队列中的10%-30%可被归类为患有痴呆的PD患者。
临床使用和治疗管理需要未来统一诊断PD痴呆的指南。
