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女性月经周期中与血浆雌激素和孕激素相关的癫痫发作。

Epileptic seizures in women related to plasma estrogen and progesterone during the menstrual cycle.

作者信息

Bäckström T

出版信息

Acta Neurol Scand. 1976 Oct;54(4):321-47. doi: 10.1111/j.1600-0404.1976.tb04363.x.

DOI:10.1111/j.1600-0404.1976.tb04363.x
PMID:973554
Abstract

Nine periods in seven women with partial epilepsy have been invetigated with respect to frequency of fits, and estrogen-progesterone levels in blood plasma. Six cycles with ovulation showed a positive correlation between the number of secondary generalized seizures and the mean estrogen/progesterone (E/P) ratios and a negative correlation to plasma progesterone levels. Three periods without ovulation showed an increase in the number of fits during days of high estrogen. The number of fits seemed not to be correlated to changes in body weight.

摘要

对7名部分性癫痫女性的9个月经周期进行了研究，涉及发作频率以及血浆中的雌激素和孕酮水平。6个有排卵的周期显示，继发性全身性发作次数与平均雌激素/孕酮（E/P）比值呈正相关，与血浆孕酮水平呈负相关。3个无排卵周期显示，在雌激素水平高的日子里发作次数增加。发作次数似乎与体重变化无关。

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