Latman N S
Am J Med. 1983 Jun;74(6):957-60. doi: 10.1016/0002-9343(83)90789-1.
Since progesterone and estrogen have been shown to exhibit anti-inflammatory/anti-arthritic activity, women with rheumatoid arthritis might be expected to have a reduction of some symptoms of rheumatoid arthritis during the postovulatory phase of the menstrual cycle when the plasma concentrations of these hormones increase. Daily examination of symptoms during 69 menstrual cycles in 14 patients with rheumatoid arthritis revealed that rheumatoid arthritis was significantly reduced during the postovulatory phase of the menstrual cycle. This reduction was clinically and statistically significant. The data presented in this report indicate that some of the "spontaneous" fluctuations in rheumatoid arthritis symptoms may be the result of changes in plasma concentrations of estrogen and progesterone.
由于已证明孕酮和雌激素具有抗炎/抗关节炎活性，因此类风湿性关节炎女性在月经周期的排卵后期，当这些激素的血浆浓度升高时，类风湿性关节炎的某些症状可能会减轻。对14名类风湿性关节炎患者69个月经周期的症状进行每日检查发现，在月经周期的排卵后期类风湿性关节炎症状明显减轻。这种减轻在临床和统计学上均具有显著意义。本报告中的数据表明，类风湿性关节炎症状的一些“自发”波动可能是雌激素和孕酮血浆浓度变化的结果。
