al-Bader A A, Mathew T C, Abul H, al-Mosawi M, Panigrahi D, Dashti H
Faculty of Medicine, Kuwait University Health Sciences Centre, Safat, Kuwait.
J R Coll Surg Edinb. 1998 Aug;43(4):278-82.
Cirrhotic liver is predisposed to bacterial infections. Different species of bacteria including Escherichia coli, Enterobacter and Bacteroides fragilis were found to colonize thioacetamide-induced cirrhotic rat liver. Zinc treatment of the cirrhotic rats significantly corrected the histological and histochemical changes in the liver. However, this reversal with zinc treatment was not accompanied by any change in the bacterial colonies in the liver. The study shows that cirrhosis predisposes liver to bacterial colonization and the process is not reversible despite the partial reversal of the cirrhotic changes.
肝硬化肝脏易发生细菌感染。已发现包括大肠杆菌、肠杆菌和脆弱拟杆菌在内的不同种类细菌定植于硫代乙酰胺诱导的肝硬化大鼠肝脏。对肝硬化大鼠进行锌治疗可显著纠正肝脏的组织学和组织化学变化。然而，锌治疗带来的这种逆转并未伴随肝脏细菌菌落的任何变化。该研究表明，肝硬化使肝脏易发生细菌定植，尽管肝硬化变化有所部分逆转，但这一过程是不可逆的。
