新型琥珀酸N-哌嗪基烷基酰亚胺的合成及其抗惊厥特性
Synthesis and anticonvulsant properties of new N-piperazinylalkyl imides of succinic acid.
作者信息
Obniska J, Kulig K, Zejc A
机构信息
Department of Pharmaceutical Chemistry, Collegium Medicum of the Jagiellonian University, Kraków, Poland.
出版信息
Acta Pol Pharm. 1998 May-Jun;55(3):223-31.
PMID:9735703
Abstract
A number of N-[(4-aryl)- or (4-methyl)-l-piperazinyl)alkyl]imides of 3-aryl or 3,3-pentamethylenesuccinic acid were synthesized and tested for anticonvulsant activity in the maximum electroshock seizure (MES) and pentylenetetrazole seizure threshold (scMet) tests. Structures of the novel compounds were confirmed by elemental and spectral analyses.
摘要
合成了多种3-芳基或3,3-亚戊基琥珀酸的N-[(4-芳基)-或(4-甲基)-1-哌嗪基]烷基酰亚胺，并在最大电休克惊厥（MES）和戊四氮惊厥阈值（scMet）试验中测试了其抗惊厥活性。通过元素分析和光谱分析确定了新型化合物的结构。
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