一些2-N-（邻苯二甲酰亚胺基）-1-烷基酯的合成与抗惊厥活性
Synthesis and anticonvulsant activity of some 2-N-(phthalimido)-1-alkyl esters.
作者信息
Marona H, Kieć-Kononowicz K
机构信息
Department of Chemical Technology of Drugs, Collegium Medicum, Jagiellonian University, Kraków, Poland.
出版信息
Pharmazie. 1998 Sep;53(9):603-6.
PMID:9770208
Abstract
Synthesis and physicochemical properties of new 2-N-(phthalimido)-1-alkyl esters are described. Esters were synthesized from aromatic and heterocyclic acids with appropriate bromoalkyl phthalimides in the presence of 1,8-diazabicyclo[5,4,0]-undec-7-ene or triethylamine. The obtained compounds were evaluated for anticonvulsant activity. The display protection against MES and ScMet-induced seizures.
摘要
描述了新型2-N-(邻苯二甲酰亚胺基)-1-烷基酯的合成及其物理化学性质。酯是由芳香族和杂环酸与适当的溴代烷基邻苯二甲酰亚胺在1,8-二氮杂双环[5,4,0]-十一碳-7-烯或三乙胺存在下合成的。对所得化合物进行了抗惊厥活性评估。它们对最大电休克（MES）和戊四氮（ScMet）诱导的癫痫发作具有保护作用。
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