Yang Q, Mao W H, Ferre I, Bayón J E, Mao X Z, González-Gallego J
College of Veterinary Medicine, Nanjing Agricultural University, Jiangsu, China.
Vet Parasitol. 1998 Jul 31;78(2):129-36. doi: 10.1016/s0304-4017(98)00134-4.
The effect of chronic Fasciola hepatica infection on the activity of plasma aspartate aminotransferase (AST), glutamate dehydrogenase (GLDH) and gamma-glutamyl transpeptidase (GGT) was investigated in water buffaloes dosed daily with 60 F. hepatica metacercariae over 20 days. Experimental fluke infection caused no clinical signs but provoked an increase in plasma level of IgG directed against F. hepatica from 4 weeks after infection. There was a significant increase in plasma AST from 6 weeks post-infection. Maximal values were reached at 14 weeks and remained significantly elevated by 23 weeks. Plasma GLDH was significantly elevated from 6 to 21 weeks post-infection. Significant increases in plasma GGT occurred from 8 to 26 weeks post-infection, reaching maximal values at 15 weeks. This study shows that plasma enzyme activities may be useful in studies of fluke-induced liver damage in water buffaloes.
在连续20天每天给水牛投喂60个肝片吸虫囊蚴的实验中，研究了慢性肝片吸虫感染对水牛血浆天冬氨酸转氨酶（AST）、谷氨酸脱氢酶（GLDH）和γ-谷氨酰转肽酶（GGT）活性的影响。实验性吸虫感染未引起临床症状，但自感染后4周起，针对肝片吸虫的血浆IgG水平升高。感染后6周血浆AST显著升高。在14周时达到最大值，并在23周时仍显著升高。感染后6至21周血浆GLDH显著升高。感染后8至26周血浆GGT显著升高，在15周时达到最大值。本研究表明，血浆酶活性可能有助于水牛吸虫性肝损伤的研究。
