Jacobson D M, Vierkant R A
Department of Neurology, Marshfield Clinic, Marshfield Medical Research Foundation, Wisconsin 54449, USA.
J Neuroophthalmol. 1998 Sep;18(3):171-5.
To determine whether the degree of cholinergic supersensitivity of the pupil differs in patients with preganglionic injury of the oculomotor nerve (third nerve palsy) compared with patients with postganglionic injury (Adie's pupil).
In this retrospective study, the authors first identified 11 patients with oculomotor nerve palsy and 11 patients with unilateral Adie's pupil who demonstrated supersensitive pupillary responses using dilute pilocarpine. The same methods for testing supersensitivity of the iris sphincter, and for defining its presence, had been used in both groups of patients. Pupil diameters of the affected and unaffected fellow eye were measured directly from self-developing photographs obtained before and 30 minutes after pilocarpine 0.1% was applied to both eyes. The amount of absolute constriction of the affected pupil, as well as the net constriction of the affected pupil (i.e., the amount of pilocarpine-induced constriction of the unaffected pupil subtracted from the amount of pilocarpine-induced constriction of the affected pupil), was compared between the two groups of patients using the Mann-Whitney test.
No significant differences were identified in any of the comparisons.
The degree of cholinergic supersensitivity of the iris sphincter appears to be similar regardless of whether the site of injury along the parasympathetic pathway of the oculomotor nerve is preganglionic or postganglionic.
确定动眼神经节前损伤患者（动眼神经麻痹）与节后损伤患者（阿-罗瞳孔）相比，瞳孔胆碱能超敏反应的程度是否存在差异。
在这项回顾性研究中，作者首先确定了11例动眼神经麻痹患者和11例单侧阿-罗瞳孔患者，这些患者使用稀释的毛果芸香碱表现出超敏瞳孔反应。两组患者均采用相同的检测虹膜括约肌超敏反应及其存在的方法。在双眼应用0.1%毛果芸香碱之前和之后30分钟拍摄的自显影片上直接测量患眼和未患眼的瞳孔直径。使用曼-惠特尼检验比较两组患者患侧瞳孔的绝对收缩量以及患侧瞳孔的净收缩量（即，从患侧瞳孔毛果芸香碱诱导的收缩量中减去未患侧瞳孔毛果芸香碱诱导的收缩量）。
在任何比较中均未发现显著差异。
无论动眼神经副交感神经通路损伤部位是节前还是节后，虹膜括约肌胆碱能超敏反应的程度似乎相似。
