Bourgon P, Pilley F J, Thompson H S
Am J Ophthalmol. 1978 Mar;85(3):373-7. doi: 10.1016/s0002-9394(14)77733-5.
In patients with unilateral Adie's syndrome, we compared the relative supersensitivity of the tonic pupil to methacholine hydrochloride (Mecholyl 2.5%) and pilocarpine 0.125%. We tested a large series of patients and photographed the pupils before and 30 minutes after the eyedrops. In a group of 36 patients, Mecholyl was positive in 64% of the tests; and in a group of 20 patients, pilocarpine 0.125% was positive in 80% of the tests. Eight patients who failed to show supersensitivity with Mecholyl were tested with pilocarpine and five of the eight were shown to be supersensitive. We concluded that pilocarpine, in this concentration is not only an adequate substitute for Mecholyl 2.5%, but is a more sensitive testing substance in unilateral cases, simply because it has a slightly stronger miotic action.
在单侧阿狄氏综合征患者中，我们比较了强直性瞳孔对盐酸醋甲胆碱（2.5%美加明）和0.125%毛果芸香碱的相对超敏反应。我们测试了大量患者，并在滴眼药前和滴眼药30分钟后拍摄瞳孔照片。在一组36例患者中，美加明在64%的测试中呈阳性；在一组20例患者中，0.125%毛果芸香碱在80%的测试中呈阳性。8例对美加明未表现出超敏反应的患者用毛果芸香碱进行测试，其中8例中有5例表现出超敏反应。我们得出结论，在此浓度下，毛果芸香碱不仅是2.5%美加明的合适替代品，而且在单侧病例中是一种更敏感的测试物质，仅仅是因为它的缩瞳作用稍强。
