Chandran R, Lee A G
Baylor College of Medicine, Houston, Texas 77030, USA.
J Neuroophthalmol. 1998 Sep;18(3):176-7.
We report rising tumor marker levels of CA 15.3 as the presenting manifestation of metastatic breast cancer to the cavernous sinus and orbit. A 39-year-old woman with a history of breast cancer developed increasing levels of tumor marker CA15.3. Ten months later, she developed vision loss in the right eye, diplopia, and right-sided ptosis. A magnetic resonance scan of the head showed a mass involving the right cavernous sinus and superior orbital fissure. Biopsy of the lesion showed metastatic breast cancer. She was treated with surgery and radiotherapy and did well. Ophthalmologists should be aware of the significance of increasing levels of tumor markers, such as CA 15.3, in patients with a history of breast cancer and new neuroophthalmologic signs or symptoms.
我们报告了CA 15.3肿瘤标志物水平升高，这是转移性乳腺癌累及海绵窦和眼眶的首发表现。一名有乳腺癌病史的39岁女性，其肿瘤标志物CA15.3水平不断升高。10个月后，她出现右眼视力丧失、复视和右侧上睑下垂。头部磁共振扫描显示一个肿块累及右侧海绵窦和眶上裂。病变活检显示为转移性乳腺癌。她接受了手术和放疗，恢复良好。眼科医生应意识到，对于有乳腺癌病史且出现新的神经眼科体征或症状的患者，CA 15.3等肿瘤标志物水平升高的意义。
