Freedman J, Blanchette M
St Michael's Hospital, University of Toronto, Ontario, Canada.
Acta Paediatr Suppl. 1998 Jun;424:3-6. doi: 10.1111/j.1651-2227.1998.tb01226.x.
Purpura has been recognized since ancient times and its clinical syndromes were refined by important observations in the sixteenth, seventeenth and eighteenth centuries. It required the development of adequate microscopes in the nineteenth century, however, to recognize the platelet, leading to the recognition of the thrombocytopenic component of ITP. The twentieth century brought recognition of the pathophysiology of the disorder and further defined the clinical states and treatments for ITP. The latter half of the twentieth century has focussed on the autoimmune components of ITP, initially on the humoral immune aspects and more recently on dysregulation of cellular immunity.
紫癜自古以来就已被认识，其临床综合征在16、17和18世纪通过重要观察得以细化。然而，直到19世纪足够先进的显微镜得以发展，才识别出血小板，进而认识到免疫性血小板减少性紫癜（ITP）的血小板减少成分。20世纪人们认识到了该疾病的病理生理学，并进一步明确了ITP的临床状态和治疗方法。20世纪后半叶聚焦于ITP的自身免疫成分，最初关注体液免疫方面，最近则关注细胞免疫失调。
