Wadenvik H, Stockelberg D, Hou M
Department of Internal Medicine, Sahlgrenska University Hospital, University of Göteborg, Sweden.
Acta Paediatr Suppl. 1998 Jun;424:26-36. doi: 10.1111/j.1651-2227.1998.tb01230.x.
Idiopathic thrombocytopenic purpura (ITP), caused by autoantibodies directed against certain platelet antigens, is the most common entity of the immune thrombocytopenias. ITP is an acquired disorder and can affect both children and adults. However, the clinical syndromes of ITP are distinct between children and adults. Childhood (acute) ITP characteristically is acute in onset, occurs within 1-2 weeks of an infection, usually of viral origin, resolves spontaneously within 6 months. Adult (chronic) ITP has an insidious onset and rarely resolves spontaneously. Over the last decade considerable new information has accumulated as to the pathophysiological mechanisms of immune thrombocytopenias. In addition, most of the knowledge on this disorder has been obtained from studies of adult patients with chronic ITP. The present work gives an updated overview of the platelet autoantigens and the molecular immunological reactions in ITP.
特发性血小板减少性紫癜（ITP）是由针对某些血小板抗原的自身抗体引起的，是免疫性血小板减少症中最常见的类型。ITP是一种获得性疾病，可影响儿童和成人。然而，ITP的临床综合征在儿童和成人之间有所不同。儿童（急性）ITP的特点是起病急，在感染（通常为病毒感染）后1-2周内发生，通常在6个月内自发缓解。成人（慢性）ITP起病隐匿，很少自发缓解。在过去十年中，关于免疫性血小板减少症的病理生理机制积累了大量新信息。此外，关于这种疾病的大多数知识都是从对成年慢性ITP患者的研究中获得的。本研究对ITP中的血小板自身抗原和分子免疫反应进行了最新概述。
