Winiarski J
Department of Paediatrics, Huddinge University Hospital, Karolinska Institute, Sweden.
Acta Paediatr Suppl. 1998 Jun;424:54-6. doi: 10.1111/j.1651-2227.1998.tb01235.x.
The concepts of the pathological mechanisms in childhood idiopathic thrombocytopenic purpura (ITP) have, to a great extent, been based on clinical experience and on data generated in adults. Studies performed in children have demonstrated that platelet antigen-specific autoantibodies are present in chronic ITP and, to a lesser extent, in acute ITP. It is, however, likely that the mechanisms initiating the production of autoantibodies are different in the two entities. In acute ITP, production of autoantibodies and immune complexes is probably linked to a transient antiviral immune response. Chronic ITP in children is an autoimmune process which eventually is reversible in many cases. The initiating factors, as in other autoimmune disorders, are yet to be elucidated.
儿童特发性血小板减少性紫癜（ITP）的病理机制概念在很大程度上是基于临床经验以及成人研究得出的数据。针对儿童开展的研究表明，血小板抗原特异性自身抗体存在于慢性ITP中，在急性ITP中也有一定程度的存在。然而，引发自身抗体产生的机制在这两种情况下可能有所不同。在急性ITP中，自身抗体和免疫复合物的产生可能与短暂的抗病毒免疫反应有关。儿童慢性ITP是一种自身免疫过程，在许多情况下最终是可逆的。与其他自身免疫性疾病一样，引发因素尚待阐明。
