人血清对一种研究性糖肽LY333328以及对照药物抗金黄色葡萄球菌药效学特性的影响。
Influence of human serum on pharmacodynamic properties of an investigational glycopeptide, LY333328, and comparator agents against Staphylococcus aureus.
作者信息
Zhanel G G, Kirkpatrick I D, Hoban D J, Kabani A M, Karlowsky J A
机构信息
Department of Medical Microbiology, University of Manitoba, Winnipeg, Canada.
出版信息
Antimicrob Agents Chemother. 1998 Sep;42(9):2427-30. doi: 10.1128/AAC.42.9.2427.
Abstract
The MICs and MBCs of 15 antibiotics for two strains of Staphylococcus aureus were determined in Mueller-Hinton broth (MHB) and 90% serum-10% MHB. Subsequent experiments established that highly protein-bound antibiotics (>/=80%), such as LY333328, demonstrated higher MICs and MBCs, less killing over an 8-h interval, and shorter postantibiotic effects in 90% serum-10% MHB than in MHB alone. Albumin was demonstrated to be almost solely responsible for changes in the aforementioned pharmacodynamic parameters of LY333328.
摘要
在穆勒-欣顿肉汤（MHB）和90%血清-10% MHB中测定了15种抗生素对两株金黄色葡萄球菌的最低抑菌浓度（MIC）和最低杀菌浓度（MBC）。随后的实验表明，高蛋白结合率（≥80%）的抗生素，如LY333328，在90%血清-10% MHB中比单独在MHB中表现出更高的MIC和MBC、在8小时内杀菌作用更小以及抗生素后效应更短。已证明白蛋白几乎是导致LY333328上述药效学参数变化的唯一原因。
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