聚（1-6）-β-D-吡喃葡萄糖基-（1-3）-β-D-吡喃葡萄糖葡聚糖与头孢唑林在豚鼠模型中预防葡萄球菌伤口感染的协同作用。
Synergism between poly-(1-6)-beta-D-glucopyranosyl-(1-3)-beta-D-glucopyranose glucan and cefazolin in prophylaxis of staphylococcal wound infection in a guinea pig model.
作者信息
Kaiser A B, Kernodle D S
机构信息
Division of Infectious Diseases, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-2605, USA.
出版信息
Antimicrob Agents Chemother. 1998 Sep;42(9):2449-51. doi: 10.1128/AAC.42.9.2449.
Abstract
To determine whether the infection-preventing capability of the neutrophil-activating agent poly-(1-6)-beta-D-glucopyranosyl-(1-3)-beta-D-glucopyranose glucan (PGG-glucan) can be enhanced with antibiotic prophylaxis, we administered PGG-glucan and cefazolin, alone and in combination, to guinea pigs inoculated with isolates of staphylococci. Guinea pigs receiving both PGG-glucan and cefazolin had 50% infective doses that were 8- to 20-fold higher than those obtained with cefazolin alone and 100- to 200-fold higher than those obtained with PGG-glucan alone. PGG-glucan and cefazolin are synergistic in their ability to prevent staphylococcal wound infection.
摘要
为了确定中性粒细胞激活剂聚（1-6）-β-D-吡喃葡萄糖基-（1-3）-β-D-吡喃葡萄糖（PGG-葡聚糖）的抗感染能力是否可通过抗生素预防得到增强，我们将PGG-葡聚糖和头孢唑林单独及联合给予接种葡萄球菌分离株的豚鼠。同时接受PGG-葡聚糖和头孢唑林的豚鼠的半数感染剂量比仅用头孢唑林时高8至20倍，比仅用PGG-葡聚糖时高100至200倍。PGG-葡聚糖和头孢唑林在预防葡萄球菌伤口感染的能力方面具有协同作用。
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Antimicrob Agents Chemother. 1998 Mar;42(3):545-9. doi: 10.1128/AAC.42.3.545.
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