Ustün C, Yanik F F, Koçak I, Canbaz M A, Cayli R
Department of Obstetrics and Gynecology, Ondokuz Mayis University School of Medicine, Samsun, Turkey.
Gynecol Obstet Invest. 1998;46(3):202-5. doi: 10.1159/000010034.
Fifty adult female rats were randomly divided into five groups. Before the standard surgical procedure which consisted of creating a lesion with electrocautery over the uterus, leuprolide acetate (LA) together with its diluent, the diluent alone and medroxyprogesterone acetate (MPA) were injected to the third, fourth, and fifth groups, respectively. Ringer's lactate (RL) solution was applied intraperitoneally to the second group at the end of the surgery. Group I received no medication. Relaparotomy was performed 3 weeks later to evaluate the adhesions. The mean adhesion scores were (mean +/- SD) 2.6 +/- 0.7, 1.4 +/- 0.8, 0.9 +/- 0.6, 2.3 +/- 0.8, and 0.8 +/- 0.6 in groups I, II, III, IV, and V, respectively. The postsurgical adhesions were significantly less in the groups treated with RL, LA, and MPA.
五十只成年雌性大鼠被随机分为五组。在通过电灼子宫制造损伤的标准外科手术前，分别向第三、第四和第五组注射醋酸亮丙瑞林（LA）及其稀释剂、单独的稀释剂和醋酸甲羟孕酮（MPA）。手术结束时，向第二组腹腔内注入乳酸林格氏液（RL）。第一组未接受任何药物治疗。三周后进行再次剖腹手术以评估粘连情况。第一、二、三、四和五组的平均粘连评分分别为（均值±标准差）2.6±0.7、1.4±0.8、0.9±0.6、2.3±0.8和0.8±0.6。接受RL、LA和MPA治疗的组术后粘连明显较少。
