Ustün C, Koçak I, Akpolat I
Department of Obstetrics and Gynaecology, Ondokuz Mayis University School of Medicine, Samsun, Turkey.
J Obstet Gynaecol. 2000 Jan;20(1):78-80. doi: 10.1080/01443610063543.
Forty adult female rats were randomly divided into four groups. Before the standard surgical procedure which consisted of creating a lesion with a lancet over the right uterine horn. Group I received no medication. Ringer's lactate (RL) solution was applied intraperitoneally to Group II at the end of the surgery. Sepracoat solution was applied intraperitoneally to Group III at the onset of the surgery. Group IV randomly received Seprafilm wrapped over the entire right uterine horn. Re-laparotomy was performed 3 weeks later to evaluate the adhesions. The mean adhesion scores were (mean+/-SD) 2.90+/-0.18, 1.00+/-0.36, 0.50+/-0.17 and 0.40+/-0.16 in Groups I, II, III, IV, respectively. The postsurgical adhesions were significantly less in the groups treated with Seprafilm and Sepracoat.
40只成年雌性大鼠被随机分为四组。在标准外科手术前，该手术包括用柳叶刀在右侧子宫角处制造一个损伤。第一组不接受任何药物治疗。在手术结束时，向第二组腹腔内注射乳酸林格氏液（RL）。在手术开始时，向第三组腹腔内注射Sepracoat溶液。第四组随机接受包裹在整个右侧子宫角上的Seprafilm。3周后进行再次剖腹手术以评估粘连情况。第一、二、三、四组的平均粘连评分分别为（平均值±标准差）2.90±0.18、1.00±0.36、0.50±0.17和0.40±0.16。使用Seprafilm和Sepracoat治疗的组术后粘连明显较少。
