Shuangshoti S, Chantra K, Navalitloha Y, Charoonwatanalaoha S, Shuangshoti S
Department of Pathology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
J Med Assoc Thai. 1998 Aug;81(8):641-6.
A 76-year-old man had an atypical granular cell tumor of the neurohypophysis which showed pleomorphic nuclei, mitotic figures, and spindle-shaped cells, extremely rare findings to be encountered. Review of 45 patients with neurohypophyseal granular cell tumor revealed a ratio of 1:2 between male and female with the peak occurrence (31%) in the fifth decade, and with the mean age of 50 years. There were no patients below 20 years of age. The common clinical presentations included visual disturbances and endocrinopathies relating to sex hormones. Surgical removal was the treatment of choice. If it is possible, total extirpation should be attempted. Because of uncertain cellular origin, the lesion should be descriptively diagnosed as granular cell tumor although multiple terms have been proposed.
一名76岁男性患有神经垂体非典型颗粒细胞瘤，其具有多形性核、有丝分裂象和梭形细胞，这些都是极其罕见的表现。对45例神经垂体颗粒细胞瘤患者的回顾显示，男女比例为1:2，发病高峰（31%）在第五个十年，平均年龄为50岁。没有年龄低于20岁的患者。常见的临床表现包括视觉障碍和与性激素相关的内分泌病。手术切除是首选治疗方法。如果可能，应尝试完全切除。由于细胞起源不确定，尽管已经提出了多个术语，但该病变应描述性诊断为颗粒细胞瘤。
