Chariyalertsak S, Chariyalertsak S, Cheirsilpa A, Chindavijak K
National Cancer Institute, Bangkok, Thailand.
J Med Assoc Thai. 1998 Sep;81(9):698-704.
Using immunohistochemistry, 119 breast cancer tissues were examined for overexpression of p53 and c-erbB-2 oncogene proteins. In 46 (38.7%) of the cases p53 was overexpressed, while 35 (29.4%) demonstrated positive c-erbB-2 immunostaining. Expression of these two oncogene products was closely correlated (p < 0.01). There was no significant association between p53 protein expression and age of the patients, clinical stage, tumor size, number of involved nodes or estrogen receptor status. However, we found significant correlation between p53 protein expression and 5-year disease-free survival (p = 0.0113). In addition, the findings in this study clearly indicated that the co-overexpression of p53 and c-erbB-2 proteins was a powerful predictor for early recurrence in the patients with breast cancer.
采用免疫组织化学方法，对119例乳腺癌组织进行p53和c-erbB-2癌基因蛋白过表达检测。46例（38.7%）病例中p53过表达，35例（29.4%）显示c-erbB-2免疫染色阳性。这两种癌基因产物的表达密切相关（p<0.01）。p53蛋白表达与患者年龄、临床分期、肿瘤大小、受累淋巴结数目或雌激素受体状态之间无显著关联。然而，我们发现p53蛋白表达与5年无病生存率之间存在显著相关性（p = 0.0113）。此外，本研究结果清楚地表明，p53和c-erbB-2蛋白的共同过表达是乳腺癌患者早期复发的有力预测指标。
