Vansant J H, Baker J W
Ann Surg. 1976 Jun;183(6):629-35. doi: 10.1097/00000658-197606000-00003.
Inclusion of vagotomy and pyloroplasty in the surgical treatment of gastroesophageal reflux associated with hiatal hernia has long been controversial. To evaluate the morbidity of vagotomy in the treatment of reflux esophagitis, a retrospective study of 311 patients treated by the Hill posterior gastropexy technique of hiatal hernia repair was tabulated. Vagotomy with the anti-reflux operation was performed upon 159 patients (51%). Vagotomy was not included for 152 patients (49%). The incidence of postoperative symptoms with or without vagotomy was almost equally divided--41% without vagotomy and 47% with vagotomy. However, the major postoperative symptoms that occurred in both groups were abdominal cramps and bloating which usually disappeared in the early postoperative period and were attributed to the anti-reflux procedure and not to vagotomy. When vagotomy was included with the anti-reflux operation, the incidence and duration of long term, disabling postoperative symptoms were significantly increased. Diarrhea occurred two times more frequently. Nausea and vomiting occurred ten times more frequently and dumping was present only in vagotomized patients. Long term postoperative symptoms, judged on a basis of symptoms lasting longer than three months duration, occurred in 1% of patients without vagotomy and 26% when vagotomy was included. This study revealed that no additional protection against recurrent symptoms of gastroesophageal reflux or radiographic evidence of recurrent hiatal hernia was provided by inclusion of vagotomy. In conclusion, vagotomy is contraindicated in the treatment of gastroesophageal reflux except in the presence of peptic ulcer disease.
在食管裂孔疝相关的胃食管反流手术治疗中纳入迷走神经切断术和幽门成形术长期以来一直存在争议。为了评估迷走神经切断术在反流性食管炎治疗中的发病率,对采用希尔后路胃固定术修复食管裂孔疝的311例患者进行了回顾性研究并制成表格。159例患者(51%)在抗反流手术的同时进行了迷走神经切断术。152例患者(49%)未进行迷走神经切断术。有无迷走神经切断术的患者术后症状发生率几乎相同——未行迷走神经切断术的患者为41%,行迷走神经切断术的患者为47%。然而,两组出现的主要术后症状都是腹部绞痛和腹胀,这些症状通常在术后早期消失,是由抗反流手术引起的,而非迷走神经切断术。当迷走神经切断术与抗反流手术同时进行时,长期致残性术后症状的发生率和持续时间显著增加。腹泻发生频率增加两倍。恶心和呕吐发生频率增加十倍,倾倒综合征仅出现在接受迷走神经切断术的患者中。根据症状持续超过三个月来判断,未行迷走神经切断术的患者中1%出现长期术后症状,而行迷走神经切断术的患者中这一比例为26%。这项研究表明,纳入迷走神经切断术并不能额外预防胃食管反流复发症状或食管裂孔疝复发的影像学证据。总之,除了存在消化性溃疡疾病外,迷走神经切断术在胃食管反流治疗中是禁忌的。