Taylor E M, Lehmann A R
MRC Cell Mutation Unit, Sussex University, Falmer, Brighton, UK.
Int J Radiat Biol. 1998 Sep;74(3):277-86. doi: 10.1080/095530098141429.
To discuss the evolutionary conservation of different DNA repair processes. The proteins that carry out base excision repair show a varying degree of structural conservation, but a high level of functional complementation between species, as might be expected for a sequential pathway. In nucleotide excision repair there is a high degree of structural conservation, but few examples of functional complementation because the process involves multiprotein complexes. Repair by homologous recombination involves proteins that are highly conserved structurally. The process of repair of DNA breaks by non-homologous end-joining is conserved in eukaryotes, but the level of sequence identity of several of the proteins is fairly low and some components involved in man do not appear to have sequence homologues in yeast.
All DNA repair processes are highly conserved. The degree of structural and functional conservation varies between the different processes.
探讨不同DNA修复过程的进化保守性。进行碱基切除修复的蛋白质表现出不同程度的结构保守性，但物种间功能互补性较高，这对于一个顺序性途径来说是可以预期的。在核苷酸切除修复中，存在高度的结构保守性，但功能互补的例子较少，因为该过程涉及多蛋白复合物。同源重组修复涉及结构上高度保守的蛋白质。真核生物中通过非同源末端连接修复DNA断裂的过程是保守的，但几种蛋白质的序列同一性水平相当低，并且人类中涉及的一些组分在酵母中似乎没有序列同源物。
所有DNA修复过程都是高度保守的。不同过程之间结构和功能的保守程度有所不同。
