Feldmann A M, van Gemert G J, van de Vegte-Bolmer M G, Jansen R C
Research Institute for Plant Protection, Wageningen, The Netherlands.
Med Vet Entomol. 1998 Jul;12(3):302-12. doi: 10.1046/j.1365-2915.1998.00122.x.
We previously selected a line of the malaria vector mosquito Anopheles stephensi refractory (resistant) to the human malaria parasite Plasmodium falciparum, using in vitro infections with P. falciparum gametocytes. This report presents data on the genetic background of refractoriness. The results of F1-crosses and backcrosses show that refractoriness to P. falciparum in our A. stephensi line is autosomal and semi-dominant to susceptibility. The expression of refractoriness is apparently affected by a cytoplasmic factor. Interpretation of data from the crosses by quantitative trait locus analysis shows that one gene or two unlinked interacting autosomal genes, or groups of closely linked genes, are involved.
我们之前通过用恶性疟原虫配子体进行体外感染，筛选出了对人类疟原虫恶性疟原虫具有抗性（耐受力）的斯氏按蚊品系。本报告展示了关于抗性遗传背景的数据。F1杂交和回交的结果表明，我们的斯氏按蚊品系对恶性疟原虫的抗性是常染色体显性，对易感性呈半显性。抗性的表达显然受到细胞质因子的影响。通过数量性状基因座分析对杂交数据的解释表明，涉及一个基因、两个不连锁的相互作用常染色体基因或紧密连锁的基因群。
