Nagaraju K, Raben N, Merritt G, Loeffler L, Kirk K, Plotz P
Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA.
Clin Exp Immunol. 1998 Sep;113(3):407-14. doi: 10.1046/j.1365-2249.1998.00664.x.
Muscle is an attractive target for gene therapy and for immunization with DNA vaccines and is also the target of immunological injury in myositis. It is important therefore to understand the immunologic capabilities of muscle cells themselves. In this study, we show that proinflammatory stimuli induce the expression of other cytokines such as IL-6, transforming growth factor-beta (TGF-beta), and granulocyte-macrophage colony-stimulating factor (GM-CSF) by muscle cells themselves, as well as the up-regulation of human leucocyte antigen (HLA) class I, class II and intercellular adhesion molecule-1 (ICAM-1). Thus, muscle cells have an inherent ability to express and respond to a variety of cytokines and chemokines. The levels of HLA class I, class II and ICAM-1 in inflamed muscle may be affected by the secreted products of the stimulation.
肌肉是基因治疗和DNA疫苗免疫的一个有吸引力的靶点，也是肌炎中免疫损伤的靶点。因此，了解肌肉细胞自身的免疫能力很重要。在本研究中，我们表明促炎刺激可诱导肌肉细胞自身表达其他细胞因子，如白细胞介素-6（IL-6）、转化生长因子-β（TGF-β）和粒细胞-巨噬细胞集落刺激因子（GM-CSF），以及上调人类白细胞抗原（HLA）I类、II类和细胞间黏附分子-1（ICAM-1）。因此，肌肉细胞具有表达和响应多种细胞因子和趋化因子的内在能力。炎症肌肉中HLA I类、II类和ICAM-1的水平可能受刺激分泌产物的影响。
