小鼠体内结核分枝杆菌生长期间CD4和CD8 T细胞的细胞因子产生情况。
Cytokine production by CD4 and CD8 T cells during the growth of Mycobacterium tuberculosis in mice.
作者信息
Howard A D, Zwilling B S
机构信息
Department of Microbiology, The Ohio State University, Columbus 43210, USA.
出版信息
Clin Exp Immunol. 1998 Sep;113(3):443-9. doi: 10.1046/j.1365-2249.1998.00674.x.
Abstract
Changes in the pattern of cytokines found in CD4 and CD8 T cells during the growth of Mycobacterium tuberculosis that resulted in the establishment of a latent infection were monitored. Subsets of T cells were identified based on their differential expression of CD45 and CD44 which allowed them to be classified as naive, activated or memory. We found that the T cells in the lung produced a predominantly type 1 cytokine response. The appearance of large numbers of Th1 cells coincided with the establishment of latency. In contrast, the predominant response in the mediastinal lymph node and spleen was a Th2-type response.
摘要
监测了结核分枝杆菌生长过程中CD4和CD8 T细胞中细胞因子模式的变化，这些变化导致了潜伏感染的建立。根据T细胞表面CD45和CD44的差异表达来识别其亚群，从而将它们分为初始、活化或记忆T细胞。我们发现，肺中的T细胞主要产生1型细胞因子反应。大量Th1细胞的出现与潜伏感染的建立同时发生。相比之下，纵隔淋巴结和脾脏中的主要反应是Th2型反应。
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本文引用的文献
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