Tyring S K
Department of Microbiology/Immunology, University of Texas Medical Branch, Galveston 77555, USA.
Clin Ther. 1998 Jul-Aug;20(4):661-70. doi: 10.1016/s0149-2918(98)80129-x.
Shingles (herpes zoster) is the result of reactivation of varicella-zoster virus after years of latency. The acute phase is self-limiting but is often associated with moderate-to-severe pain; postherpetic neuralgia is the most frequent and debilitating complication of shingles, occurring in 3.4 per 1000 individuals per year. In the case of genital herpes, herpes simplex virus can reactivate to cause recurrent episodes as often as several times a year, sometimes for the remainder of a person's life. Antiviral agents such as famciclovir, valacyclovir, and acyclovir can be used to shorten the course and decrease the severity of these diseases and may suppress the virus itself, thereby preventing future outbreaks of genital herpes. This article presents a brief synopsis of the etiology of herpes zoster and genital herpes and reviews 12 key studies that demonstrate the efficacy of famciclovir in the management of these two conditions.
带状疱疹（herpes zoster）是水痘-带状疱疹病毒潜伏多年后重新激活的结果。急性期具有自限性，但常伴有中度至重度疼痛；带状疱疹后神经痛是带状疱疹最常见且使人衰弱的并发症，每年每1000人中就有3.4人发病。对于生殖器疱疹，单纯疱疹病毒可重新激活，导致每年复发数次，有时会持续至患者余生。泛昔洛韦、伐昔洛韦和阿昔洛韦等抗病毒药物可用于缩短病程、减轻这些疾病的严重程度，还可能抑制病毒本身，从而预防未来生殖器疱疹的发作。本文简要概述了带状疱疹和生殖器疱疹的病因，并回顾了12项关键研究，这些研究证明了泛昔洛韦在治疗这两种病症方面的疗效。
