Spellman M C, Pincus S H
University of California at San Diego and VA Medical Center, USA.
Clin Ther. 1998 Jul-Aug;20(4):711-21. doi: 10.1016/s0149-2918(98)80134-3.
We conducted a 12-week, multicenter, randomized, double-masked, parallel-group study of the efficacy, safety, and tolerability of azelaic acid 20% cream and glycolic acid lotion compared with tretinoin 0.025% cream and a vehicle lotion to treat mild-to-moderate facial acne vulgaris. Patients treated with azelaic/glycolic acid experienced a significantly greater reduction in the number of papules, as well as a greater reduction in the number of inflammatory lesions, than those treated with tretinoin. Overall global improvement was approximately 25% in both groups. In the physician evaluations, treatment with azelaic/glycolic acid was found to cause significantly less dryness, scaling, and erythema than tretinoin. Patients also reported significantly less dryness, redness, and peeling with azelaic/glycolic acid. Significantly more patients in the azelaic/glycolic acid group than the tretinoin group reported that they felt attractive. The combination of azelaic acid and glycolic acid is a useful alternative to tretinoin, being at least as efficacious as the latter, while offering a superior tolerability and patient approval profile.
我们进行了一项为期12周的多中心随机双盲平行组研究，比较20%壬二酸乳膏和乙醇酸洗剂与0.025%维甲酸乳膏及赋形剂洗剂治疗轻至中度寻常型面部痤疮的疗效、安全性和耐受性。与维甲酸治疗组相比，使用壬二酸/乙醇酸治疗的患者丘疹数量显著减少，炎性损害数量也有更大程度的减少。两组的总体整体改善率约为25%。在医生评估中，发现壬二酸/乙醇酸治疗引起的干燥、脱屑和红斑明显少于维甲酸。患者也报告使用壬二酸/乙醇酸时干燥、发红和脱皮明显较少。与维甲酸组相比，壬二酸/乙醇酸组中报告感觉自己有吸引力的患者明显更多。壬二酸和乙醇酸的组合是维甲酸的一种有用替代方案，至少与后者疗效相当，同时具有更好的耐受性和患者接受度。
