Kakita L S, Lowe N J
Clinical Research Specialists, Santa Monica, California, USA.
Clin Ther. 1998 Sep-Oct;20(5):960-70. doi: 10.1016/s0149-2918(98)80077-5.
This multicenter, randomized, double-masked, parallel-group, 24-week clinical study compared the efficacy of the combination of azelaic acid 20% cream and glycolic acid 15% or 20% lotion with hydroquinone 4% in the treatment of facial hyperpigmentation in darker-skinned patients. At week 24, overall improvement and reduction in lesion area, pigmentary intensity, and disease severity were comparable in the two treatment groups. At some visits, patients treated with an azelaic/glycolic acid combination had slightly greater levels of peeling, burning, stinging, or dryness than did patients treated with hydroquinone, although scores for cutaneous signs and symptoms were always low. The present study demonstrated that the combination of azelaic acid 20% cream and glycolic acid 15% or 20% lotion was as effective as hydroquinone 4% cream in the treatment of hyperpigmentation in darker-skinned patients, with only a slightly higher rate of mild local irritation. These findings suggest that the addition of glycolic acid to azelaic acid treatment for hyperpigmentation is an appropriate alternative in selected darker-skinned patients.
这项多中心、随机、双盲、平行组、为期24周的临床研究比较了20%壬二酸乳膏与15%或20%乙醇酸洗剂联合使用与4%氢醌治疗深色皮肤患者面部色素沉着的疗效。在第24周时，两个治疗组在整体改善、皮损面积减少、色素沉着强度和疾病严重程度方面相当。在某些访视中，使用壬二酸/乙醇酸组合治疗的患者出现的脱皮、烧灼感、刺痛感或干燥程度略高于使用氢醌治疗的患者，尽管皮肤体征和症状评分始终较低。本研究表明，20%壬二酸乳膏与15%或20%乙醇酸洗剂联合使用在治疗深色皮肤患者色素沉着方面与4%氢醌乳膏效果相当，只是轻度局部刺激发生率略高。这些发现表明，在选定的深色皮肤患者中，在壬二酸治疗色素沉着时添加乙醇酸是一种合适的替代方法。
