Hofer B, Junginger T
Klinik für Allgemein- und Abdominalchirurgie, Universität Mainz.
Chirurg. 1998 Jul;69(7):747-52. doi: 10.1007/s001040050485.
Changes in clinical presentation of Crohn's disease (CD), patients' age at the time of disease manifestation and operation, general condition and duration of medical management were investigated in a retrospective study. 395 operations for CD were divided into consecutive groups and analysed. In an increasing number of cases patients presented with the "fibrostenotic type" rather than the "fistulizing type" of complaints. The duration of disease and of medical management increased. Patients in later groups were younger and in better general condition. We found a rise in frequency of patients with recurrent CD or prior abdominal surgery for other reasons. Primary surgery for CD increasingly consisted of resection of solitary segments of gut; in the case of recurrence, of multiple, minimal resections. The average total length of the resected intestine could be significantly reduced. The complication rate was equal in elective and emergency surgery.
在一项回顾性研究中,对克罗恩病(CD)临床表现的变化、疾病表现及手术时患者的年龄、一般状况和药物治疗持续时间进行了调查。将395例CD手术分为连续几组并进行分析。越来越多的病例中,患者表现出“纤维狭窄型”而非“瘘管型”的症状。疾病和药物治疗的持续时间增加。后期组的患者更年轻,一般状况更好。我们发现复发性CD患者或因其他原因曾接受腹部手术的患者频率有所上升。CD的初次手术越来越多地包括切除肠道的单个节段;复发时则进行多次微小切除。切除肠段的平均总长度可显著缩短。择期手术和急诊手术的并发症发生率相同。