Archer S L, Liu K, Dyer A R, Ruth K J, Jacobs D R, Van Horn L, Hilner J E, Savage P J
Northwestern University Medical School, Department of Preventive Medicine, Chicago, IL 60611, USA.
Ann Epidemiol. 1998 Oct;8(7):433-8. doi: 10.1016/s1047-2797(98)00007-6.
Cross-sectional data from several observational studies have suggested that dietary sucrose may be inversely associated with high density lipoprotein cholesterol (HDL-C). This study examined associations between energy from dietary sucrose and HDL-C at baseline, year 7 and longitudinally (year 7 minus baseline) in a cohort of young black and white men and women from the Coronary Artery Risk Development in Young Adults (CARDIA) study.
The sample included 4734 black men, black women, white men and white women, ages 18-30 years, in 1985-86 (baseline); 3513 at year 7; and 3335 for longitudinal analyses. Multivariate analyses was used with adjustment for age, BMI, cigarettes smoked per day, physical activity score, and alcohol intake.
Multivariate analyses indicated that energy intake from sucrose was inversely associated with HDL-C for each race-gender group at baseline, year 7, and longitudinally from baseline to year 7. This association was significant at baseline for black men, and white men and women (p < 0.01); at year 7 for white men and black women (p < 0.01), and longitudinally for white men, white women, and black women (p < 0.05).
The consistent inverse associations between energy from dietary sucrose and HDL-C observed in both cross-sectional and longitudinal analyses, and in different race and gender groups in CARDIA suggest that lowering dietary sucrose intake may be beneficial for those who may have low HDL-C.
多项观察性研究的横断面数据表明，膳食蔗糖可能与高密度脂蛋白胆固醇（HDL-C）呈负相关。本研究在来自青年动脉粥样硬化风险发展研究（CARDIA）的年轻黑人和白人男性及女性队列中，考察了基线、第7年时膳食蔗糖能量与HDL-C之间的关联，以及纵向（第7年减去基线）关联。
样本包括1985 - 1986年（基线）时年龄在18 - 30岁的4734名黑人男性、黑人女性、白人男性和白人女性；第7年时为3513人；用于纵向分析的为3335人。采用多变量分析，并对年龄、体重指数、每日吸烟量、身体活动评分和酒精摄入量进行了调整。
多变量分析表明，在基线、第7年以及从基线到第7年的纵向分析中，每个种族 - 性别组中蔗糖的能量摄入均与HDL-C呈负相关。这种关联在基线时对黑人男性、白人男性和女性具有显著性（p < 0.01）；在第7年时对白人男性和黑人女性具有显著性（p < 0.01），在纵向分析中对白人男性、白人女性和黑人女性具有显著性（p < 0.05）。
在CARDIA研究的横断面和纵向分析中，以及在不同种族和性别组中观察到的膳食蔗糖能量与HDL-C之间一致的负相关表明，降低膳食蔗糖摄入量可能对HDL-C水平较低的人有益。
