浴用补骨脂素紫外线A光化学疗法中的光敏反应动力学
Kinetics of photosensitivity in bath-PUVA photochemotherapy.
作者信息
Gruss C, Behrens S, Reuther T, Husebo L, Neumann N, Altmeyer P, Lehmann P, Kerscher M
机构信息
Department of Dermatology, Ruhr-University Bochum, Germany.
出版信息
J Am Acad Dermatol. 1998 Sep;39(3):443-6. doi: 10.1016/s0190-9622(98)70322-6.
BACKGROUND
Bath-PUVA is used to treat a variety of dermatoses. However, the kinetics of 8-methoxypsoralen during treatment are not completely clarified.
OBJECTIVE
The purpose of this study was to investigate the intensity of the phototoxic response and the persistence of phototoxicity after bath-PUVA.
METHODS
Twelve volunteers were exposed to UVA doses ranging from 0.5 to 40 J/cm2 from 10 to 240 minutes after bath-PUVA treatment. The resulting phototoxic response of the skin was determined.
RESULTS
Irradiation 10 minutes after the psoralen bath led to the lowest assessed minimal phototoxic dose (MPD) of 1.42 J/cm2 (mean, SD +/- 0.29). Thereafter, the MPD increased significantly and sharply every hour. At 4 hours after the psoralen bath, UVA doses up to 40 J/cm2 failed to induce any phototoxic erythema (MPD).
CONCLUSION
For optimal effects, UVA irradiation has to be administered immediately after the psoralen bath; no restrictive behavior is necessary after bath-PUVA treatment.
背景
浴用补骨脂素联合紫外线A（Bath-PUVA）用于治疗多种皮肤病。然而，治疗期间8-甲氧基补骨脂素的动力学尚未完全阐明。
目的
本研究的目的是调查浴用补骨脂素联合紫外线A治疗后光毒性反应的强度和光毒性的持续时间。
方法
12名志愿者在浴用补骨脂素联合紫外线A治疗后10至240分钟接受0.5至40 J/cm²的紫外线A照射剂量。测定皮肤由此产生的光毒性反应。
结果
补骨脂素浴后10分钟照射导致评估的最低最小光毒性剂量（MPD）为1.42 J/cm²（平均值，标准差±0.29）。此后，MPD每小时显著且急剧增加。在补骨脂素浴后4小时，高达40 J/cm²的紫外线A剂量未能诱导任何光毒性红斑（MPD）。
结论
为获得最佳效果，紫外线A照射必须在补骨脂素浴后立即进行；浴用补骨脂素联合紫外线A治疗后无需采取限制性行为。
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