Ellison M D, Hung R T, Harris K, Campbell B H
Department of Otolaryngology and Human Communication, Medical College of Wisconsin, Milwaukee 53226, USA.
Arch Otolaryngol Head Neck Surg. 1998 Sep;124(9):1014-6. doi: 10.1001/archotol.124.9.1014.
Scopulariopsis acremonium is a species of saprophytic fungus not previously reported to cause invasive disease in humans, although invasive infections from other species of Scopulariopsis have been reported and are reviewed. Deep infection with this fungus is associated with a high mortality rate. Invasive fungal sinusitis, in general, is a potentially fatal disease that typically affects immunocompromised patients, such as those receiving intensive chemotherapy or undergoing bone marrow transplantation. We report a case of invasive fungal sinusitis caused by Scopulariopsis acremonium in a patient with leukemia, who was successfully treated with amphotericin B, itraconazole, endoscopic sinus surgery, and granulocyte colony-stimulating factor.
顶头孢帚霉是一种腐生真菌，此前未有导致人类侵袭性疾病的报道，不过其他帚霉属物种引起的侵袭性感染已有报道并进行了综述。这种真菌的深部感染与高死亡率相关。一般来说，侵袭性真菌性鼻窦炎是一种潜在的致命疾病，通常影响免疫功能低下的患者，如接受强化化疗或进行骨髓移植的患者。我们报告了一例白血病患者发生顶头孢帚霉引起的侵袭性真菌性鼻窦炎的病例，该患者通过两性霉素B、伊曲康唑、鼻内镜鼻窦手术和粒细胞集落刺激因子成功治愈。
